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The AHS Guidelines: 2018 Updates - Guidance on Prevention, Testing and Treatment

Guidance on Prevention, Testing and TreatmentAHS Jul 18 Summer Bulletin PDF

by Tom Nelson, DVM

Open/Download Quarterly Update as PDF

While heartworms are a tough opponent, knowledge is a powerful weapon. To arm veterinarians with the most up-to-date and comprehensive information about heartworm management, the American Heartworm Society (AHS) created guidelines on heartworm prevention, testing and treatment, as well as heartworm epidemiology and biology. Guideline revisions are published as needed, based on sound principles of heartworm management. The 2018 guidelines include the following recommendations.

Weigh the RiskHEARTWORM PREVENTION: Weigh the Risk

Heartworms have been diagnosed in all 50 states, but the risk of transmission varies considerably. Veterinarians should weigh the relative risk of heartworm infection when making specific heartworm prevention recommendations to clients.

We suggest that veterinarians:

  • Recommend year-round prevention with a macrocyclic lactone preventive for all pets.
  • Take practical steps to limit mosquito exposure (e.g., keeping pets indoors during peak mosquito times and eliminating standing water where mosquitoes can breed).
  • If mosquito proliferation and the presence of heartworm-positive animals means the risk of heartworm transmission is high, consider adding a mosquito repellent/ectoparasticide seasonally or year-round. Don’t rely on repellents alone to prevent heartworm disease.

Know When to Heat the SampleHEARTWORM TESTING: Know When to Heat the Sample

The practice of heating serum samples prior to antigen testing to unmask blocked antigen has been the subject of multiple scientific studies designed to determine optimal heartworm testing methods.

For veterinarians who have questions about heat treatment, the AHS recommends:

  • Rely on antigen and microfilaria testing for routine heartworm screening. These tests are highly sensitive and accurate.
  • Because heat treatment is contrary to labeling for in-house antigen tests and may interfere with the accuracy of certain blood tests, don’t heat-treat samples as part of routine screening.
  • Consider heat treating a patient’s serum sample if clinical infection in the absence of a positive antigen test result is suspected.

Avoid AlternativesHEARTWORM TREATMENT: Avoid Alternatives

The goal of heartworm treatment is to kill adult worm infections with minimal complications while stopping the progression of disease. Alternative, nonarsenical-based treatment protocols have been studied to guide management of dogs that aren’t candidates for melarsomine treatment; however, the treatment protocol recommended by the AHS includes pre-treatment with an ML and doxycycline, following by a month-long waiting period, then 3 doses of melarsomine on days 60, 90 and 91.

Here’s why:

  • Waiting until day 60 to start killing the adult worms with melarsomine allows time for Wolbachia surface proteins and other metabolites to dissipate, as well as time for the heartworms themselves to wither.
  • While non-arsenical treatment protocols have their place for a small percentage of dogs, it can take much longer to kill adult worms, during which time heartworm pathology and damage can progress.

To access the complete set of AHS canine and feline heartworm guidelines, visit


The days are getting shorter, the nights are cooler, leaves are starting to turn, and football season is here. But that doesn’t mean your clients can forget about protecting their pets from heartworms.

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